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Article

Transcriptional activation of REST by Sp1 in Huntington's disease models.

PloS one - 14 Dec 2010

Ravache Myriam, Weber Chantal, Mérienne Karine, Trottier Yvon

Abstract excerpt

In Huntington's disease (HD), mutant huntingtin (mHtt) disrupts the normal transcriptional program of disease neurons by altering the function of several gene expression regulators such as Sp1. REST (Repressor Element-1 Silencing Transcription Factor), a key regulator of neuronal differentiation, is also aberrantly activated in HD by a mechanism that remains unclear. Here, we show that the level of REST mRNA is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21179468
DOI: 10.1371/journal.pone.0014311
PMCID: PMC3001865

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional activation of REST by Sp1 in Huntington's disease models.PMID 21179468Read ↗

Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.Semantic proximity Read ↗

Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic StrategiesSemantic proximity Read ↗

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.Semantic proximity Read ↗

<i>REST</i> and <i>RCOR</i> genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell modelsSemantic proximity Read ↗

Sp1 regulates human huntingtin gene expression.Semantic proximity Read ↗

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.Semantic proximity Read ↗

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.Semantic proximity Read ↗

Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.Semantic proximity Read ↗

Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation.Semantic proximity Read ↗

CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesisSemantic proximity Read ↗

Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.Semantic proximity Read ↗

Alternative <i>REST</i> Splicing UnderappreciatedSemantic proximity Read ↗

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