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Article

Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators.

The European journal of neuroscience - 1 Oct 2001

Lietz M, Bach K, Thiel G

Abstract excerpt

The zinc finger protein RE-1 silencing transcription factor (REST) is a transcriptional repressor that represses neuronal genes in non-neuronal tissues. We have analyzed the ability of REST and the REST mutants, RESTDeltaN and RESTDeltaC lacking either the N-terminal or C-terminal repression domains of REST, to inhibit transcription mediated by distinct transcriptional activator proteins. For this purpose we have...

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Identifiers

PMID: 11703459
DOI: 10.1046/j.0953-816x.2001.01762.x

Genes

REST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators.PMID 11703459Read ↗

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SIRT6-dependent functional switch via K494 modifications of RE-1 Silencing Transcription factorSemantic proximity Read ↗

Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic StrategiesSemantic proximity Read ↗

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.Semantic proximity Read ↗

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer.Semantic proximity Read ↗

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampusSemantic proximity Read ↗

Whole genome functional characterization of RE1 silencers using a modified massively parallel reporter assaySemantic proximity Read ↗

Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors.Semantic proximity Read ↗

Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication.Semantic proximity Read ↗

Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.Semantic proximity Read ↗

The Importance of REST for Development and Function of Beta CellsSemantic proximity Read ↗

<i>REST</i> and <i>RCOR</i> genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell modelsSemantic proximity Read ↗

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