Article

miR-10b Deficiency Affords Atherosclerosis Resistance

2018-01-16

Abstract excerpt

Human vascular endothelial cells (ECs) are categorized into two groups; pro-stenotic (Type-I) and anti-stenotic (Type-II) ECs, and one of the master genes for a stress-induced “Type-II-to-Type-I” degeneration is Regulator of G-protein signaling 5 (RGS5). Here we show that miR-10b is a crucial downstream mediator in RGS5-dependent degeneration. We also demonstrated the miR-10b high Type-I EC exosome has a trans ef...

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Literature Corpus work: 5ce6e620-8666-586f-a3f2-ae0c9274c9c2
DOI: 10.1101/248641

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