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Inhibiting Anti-angiogenic VEGF165b Activates a Novel miR-17-20a-Calcipressin-3 Pathway that Revascularizes Ischemic Muscle in Peripheral Artery Disease

2023-08-14

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>VEGF165a increases the expression of microRNA-17-92 cluster, promoting developmental, retinal, and tumor angiogenesis. We have previously shown that VEGF165b, an alternatively spliced VEGF-A isoform, inhibits the VEGFR-STAT3 pathway in ischemic endothelial cells (ECs) to decrease their angiogenic capacity. In ischemic macrophages (Møs), VEG...

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Literature Corpus work: 6c58fd8e-3e0a-572b-af2f-32e4303af46f
DOI: 10.21203/rs.3.rs-3213504/v1

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