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Article

Transforming growth factor-betas and vascular disorders.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2006

Bobik Alex

Abstract excerpt

Transforming growth factor-beta (TGF-beta) superfamily members, TGF-beta and bone morphogenetic proteins (BMPs), are potent regulatory cytokines with diverse functions on vascular cells. They signal through heteromeric type I and II receptor complexes activating Smad-dependent and Smad-independent signals, which regulate proliferation, differentiation, and survival. They are potent regulators of vascular...

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Identifiers

PMID: 16675726
DOI: 10.1161/01.ATV.0000225287.20034.2c

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ALK

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