CREG mediated adventitial fibroblast phenotype modulation: a possible therapeutic target for proliferative vascular disease.

Abstract excerpt

Proliferative vascular diseases, of which neointimal formation is a key pathological feature, cause significant morbidity and mortality worldwide. Adventitia is the outermost connective tissue that surrounds an artery. In recent years, accumulating data indicate that adventitial fibroblasts participate in the formation of neointimal lesions. Our previous studies have demonstrated that cellular repressor of...

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