Article
MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.
FEBS letters - 20 Dec 2014
Zeng Yan, Pan Yanping, Liu Hongtai, Kang Kang, Wu Yike, Hui Gang, Peng Wenda, Ramchandran Ramaswamy, Raj J Usha, Gou Deming
Abstract excerpt
Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we identified two crucial miR-20a binding sites within the...
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