Article

Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids

2021-06-02

Abstract excerpt

<h4>Summary</h4> The impact of long-term opioid exposure on the embryonic brain is crucial to healthcare due to the surging number of pregnant mothers with an opioid dependency. Current studies on the neuronal effects are limited due to human brain inaccessibility and cross-species differences among animal models. Here, we report a model to assess cell-type specific responses to acute and chronic fentanyl treatme...

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Literature Corpus work: 126df5d4-2d77-59ad-b644-14074d92a734
DOI: 10.1101/2021.06.02.446827

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