Article

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

2022-05-04

Abstract excerpt

<h4>SUMMARY</h4> 3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we established a method for generating functional neural spheroids with differentiated human induced pluripotent stem cell (hiPSC)-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain. Recordings of intracellular calcium osci...

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Literature Corpus work: 78fdba81-9622-59f0-964b-88f49973a38c
DOI: 10.1101/2022.05.04.490442

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