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Article

Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells.

Stem cells and development - 1 May 2009

Kumar Manoj, Kaushalya Sanjeev K, Gressens Pierre, Maiti Sudipta, Mani Shyamala

Abstract excerpt

The ability to study the characteristics of serotonin release from human serotonergic neurons is valuable both in terms of understanding disease pathology and in trying to understand how drugs that affect the serotonergic system alter neurotransmitter release. There is, however, no good in vitro system to model human serotonergic neurons. Although human embryonic stem (hES) cells offer an attractive model system,...

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PMID: 18800863
DOI: 10.1089/scd.2008.0181

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