Article

Human hindbrain organoids with segment-specific 5-HT neurons for motor modulation

2026-05-29

Abstract excerpt

The serotonergic system regulates human mood, reward, and motor control, and its impairment contributes to debilitating psychiatric disorders. Serotonergic neurons (SNs) arise predominantly in the hindbrain and acquire segment-specific identities and functions; however, the lack of human models remains a challenge to understanding the human serotonergic system. Here, we generate human serotonergic-enriched rostral...

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Literature Corpus work: 7fabf99b-e66d-51be-85b4-eb95101dbbae
DOI: 10.64898/2026.05.27.726154

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