Article

The physiological impact of an N-terminal Halo-tag on GIPR function in mice

2024-12-18

Abstract excerpt

<h4>Aims</h4> G protein-coupled receptors (GPCRs) modified with self-labelling enzymatic tags (e.g. Halo, SNAP, CLIP) have enabled the in vitro study of receptor expression and trafficking. We developed a Gipr Halo/Halo mouse model to gain insights into endogenous glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signalling, an important modulator of glucose and appetite homeostasis. <h4>Meth...

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Identifiers and source

Literature Corpus work: 5c9e9cc5-c862-5de3-83c8-3e016c438e04
DOI: 10.1101/2024.12.18.629103

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