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Article

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

PloS one - 1 Jan 2012

Whitaker Gina M, Lynn Francis C, McIntosh Christopher H S, Accili Eric A

Abstract excerpt

In response to a meal, Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) are released from gut endocrine cells into the circulation and interact with their cognate G-protein coupled receptors (GPCRs). Receptor activation results in tissue-selective pleiotropic responses that include augmentation of glucose-induced insulin secretion from pancreatic beta cells. N-glycosylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22412906
DOI: 10.1371/journal.pone.0032675
PMCID: PMC3296735

Genes

GIP
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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