Article

Glucagon-like peptide-1 receptor C-terminal tail phosphorylation determines signalling responses from pancreatic β-cells

2025-11-03

Abstract excerpt

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein–coupled receptor that regulates glucose homeostasis by promoting cAMP production and insulin secretion in pancreatic β-cells. Although receptor phosphorylation is known to influence GLP-1R signalling, its functional relevance in β-cells remains incompletely understood. Here, we investigated the role of three C-terminal serine doublets (Ser441/442...

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Literature Corpus work: 35bc7bed-c1f4-55d6-b4be-265172956356
DOI: 10.1101/2025.11.01.686001

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