Article

SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease

2020-09-03

Abstract excerpt

Gene regulation is known to play a fundamental role in human disease, but mechanisms of regulation vary greatly across genes. Here, we explore the contributions to disease of two types of genes: genes whose regulation is driven by enhancer regions as opposed to promoter regions (enhancer-related) and genes that regulate other genes in trans (candidate master-regulator). We link these genes to SNPs using a comprehe...

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Literature Corpus work: db2923cd-08a5-5e8d-b1ed-8f2ebfc210fa
DOI: 10.1101/2020.09.02.279059

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