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Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB.

Molecules (Basel, Switzerland) - 31 Aug 2021

Qi Rui, Bian Ke, Chen Fangyi, Tang Qi, Zhou Xianhao, Li Deyu

Abstract excerpt

Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair. Here, we consider the repair aspect of 1,N6-ethenoadenine (εA) by the 2-oxoglutarate/Fe(II)-dependent AlkB family enzymes. Specifically, we investigated εA repair across...

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PMID: 34500720
DOI: 10.3390/molecules26175285
PMCID: PMC8434105

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