Article

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer

2025-10-03

Abstract excerpt

N-Nitrosodimethylamine (NDMA), a probable human carcinogen, induces toxic and mutagenic O 6 -methylguanine lesions that are repaired by the O 6 -methylguanine methyltransferase (MGMT). To elucidate mechanisms of NDMA-induced liver cancer progression, we performed longitudinal analyses of phenomic, transcriptomic, and phosphoproteomic changes in wild-type and MGMT-deficient mice, observing amplified responses in...

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Literature Corpus work: 4d8d4316-6ea6-5a53-9523-6c54f8c9840a
DOI: 10.1101/2025.10.01.679856

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