Article

Defining mutational signatures of lung cancer-associated carcinogens through <i>in vitro</i> exposure of human airway epithelial cells

2026-03-09

Abstract excerpt

<h4>ABSTRACT</h4> While distinct environmental exposures imprint unique mutational signatures on cancer genomes, the specific causal patterns for many known carcinogens remain uncharacterized in relevant human tissues. To address this gap, we developed a novel, physiologically relevant system that uses a combination of airway epithelial cells and whole genome sequencing to characterize mutational patterns induced...

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Literature Corpus work: 3eceb23e-9e0d-53ae-9cb2-b9614c4b5b67
DOI: 10.64898/2026.03.05.707509

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