Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

Abstract excerpt

An effective cancer therapy requires both killing cancer cells and targeting tumor-promoting pathways or cell populations within the tumor microenvironment (TME). We purposely search for molecules that are critical for multiple tumor-promoting cell types and identified nuclear receptor subfamily 4 group A member 1 (NR4A1) as one such molecule. NR4A1 has been shown to promote the aggressiveness of cancer cells and...

Topics

Open a Topic to create a Post that cites this publication.

• CAR-T cell therapy research
• Integrated Circuits and Semiconductor Failure Analysis
• Multiple Myeloma Research and Treatments
• PARP inhibition in cancer therapy
• Peptidase Inhibition and Analysis
• Prostate Cancer Treatment and Research
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

5c298527-fdb4-51e3-b8bb-bacf0ed66e0b

DOI

10.1101/2023.08.09.552650