Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor Degradation

Abstract excerpt

Transcription factors (TFs) play central roles in gene regulation and disease progression but have long been considered undruggable due to the absence of well-defined binding pockets and their reliance on protein-protein or protein-DNA interactions. Proteolysis-targeting chimeras (PROTACs) offer a novel strategy to overcome these limitations by inducing selective degradation of TFs via the ubiquitin-proteasome...

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