Article

Melanoma-intrinsic NR2F6 activity regulates anti-tumor immunity

2022-09-17

Abstract excerpt

Nuclear receptors (NRs) have been implicated in tumor and immune cell regulation, most notably in hormone-dependent cancers. Here we identify a tumor-intrinsic function of the orphan nuclear receptor NR2F6 in regulating anti-tumor immunity. We selected NR2F6 among 48 candidate NRs based on an expression pattern in melanoma patient specimens coinciding with the IFNγ signature, which is associated with positive resp...

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Literature Corpus work: f914775d-aae4-5219-8f49-f3ad20f1cc7c
DOI: 10.1101/2022.09.14.508028

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