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Targeted degradation of specific TEAD paralogs by small molecule degraders

1 Sept 2024

Abstract excerpt

The transcription factors, TEAD1-4 together with their co-activator YAP/TAZ function as key downstream effectors of the Hippo pathway. Hyperactivation of TEAD-YAP/TAZ activity is observed in many human cancers. TEAD1-4 possess distinct physiological and pathological functions, with conserved sequences and structures. Targeting specific isoforms within TEAD1-4 can serve as valuable chemical probes for...

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PMID: 39328531
DOI: 10.1016/j.heliyon.2024.e37829

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