Article

Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradation

2026-02-04

Abstract excerpt

Tumor-infiltrating CD8 + T cells (TILs) show progressive loss of effector function and upregulation of inhibitory receptors. NR4A transcription factors have emerged as key regulators of this dysfunctional state. Here we developed degron-based systems enabling rapid degradation of endogenous NR4A proteins in both mouse and primary human T cells. We demonstrate that the continuous presence of each NR4A protein is r...

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Literature Corpus work: 812bd032-3b58-502d-807e-ea32f6ba0e11
DOI: 10.64898/2026.02.02.701413

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