Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis

Abstract excerpt

Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients’ survival. Identifying molecular pathways and compounds that target these pathways is critical for improving patient outcomes. RNF4, an E3-ubiquitin ligase, is pivotal in oncoprotein stabilization and DNA repair, enhancing cancer cell survival driving tumorigenesis. Elevated RNF4 levels are a...

Topics

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• Acetylation
• Cell Line, Tumor
• Models, Molecular
• Mutation
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Protein Processing, Post-Translational
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

e1902c47-8763-5a86-9b1b-ad357796ac21

DOI

10.1101/2024.12.28.630572