Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)

Abstract excerpt

<h4>ABSTRACT</h4> Indoleamine 2,3-dioxygenase 1 (IDO1) is a potently immunosuppressive protein that inhibits antitumor immunity through both tryptophan metabolism and non-enzymatic functions. Pharmacological therapies targeting IDO1 enzyme activity have generally failed to improve the overall survival of patients with cancer. Developing new therapeutic agents that are capable of neutralizing both enzyme-and non-e...

Topics

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• CAR-T cell therapy research
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

e11a0741-ab11-59f2-bd59-fe8caacb09a3

DOI

10.1101/2025.01.07.631731