Article

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

2025-07-26

Abstract excerpt

Despite advances in disease treatment, our understanding of how damaged organs recover and the mechanisms governing this process remain poorly defined. Here, we mapped the transcriptional and regulatory landscape of human cardiac recovery using single cell multiomics. Macrophages emerged as the most reprogrammed cell type. Deep learning identified the transcription factor RUNX1 as a key regulator of this process....

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Literature Corpus work: 5bf33005-03d0-5285-b00f-ebb74a0b92c0
DOI: 10.1101/2025.07.25.665779

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