Article

Multicellular signaling and partial recovery define reverse cardiac remodeling

2026-01-12

Abstract excerpt

Heart failure results from maladaptive multicellular remodeling triggered by sustained biomechanical stress. Although mechanical unloading can promote reverse remodeling, recovery is frequently incomplete and its mechanistic basis remains unclear. Using a reversible murine pressure-overload model combined with bulk and single-nucleus transcriptomics, we demonstrate that reverse remodeling represents an actively ma...

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Literature Corpus work: 252e1267-3f56-5091-941c-83c9acd9fc98
DOI: 10.64898/2026.01.12.699040

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