Article

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factors

2026-01-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> After myocardial infarction (MI), cardiac fibroblasts proliferate and undergo a sequential differentiation process. They first transition into cardiac myofibroblasts, a transient and highly contractile state, and ultimately into matrifibrocytes, a more stable state that partially resembles chondrocytes. These dynamic transitions are essential for infarct healing and scar for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b03cc3f0-eaab-5d49-99c8-8dcdda7049ef
DOI: 10.64898/2026.01.12.699153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factorsDOI 10.64898/2026.01.12.699153Read

Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasetsSemantic proximity Read

Spatial multi-omic map of human myocardial infarctionSemantic proximity Read

Targeting RUNX1 in Macrophages Facilitates Cardiac RecoverySemantic proximity Read

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac FibrosisSemantic proximity Read

Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarctionSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosisSemantic proximity Read

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read

The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarctionSemantic proximity Read

Cardiomyocytes Undergo a Mesenchymal-Like Fate Transition in Myocardial FibrosisSemantic proximity Read

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast SubpopulationsSemantic proximity Read

Fibroblast Diversity and Epigenetic Regulation in Cardiac FibrosisSemantic proximity Read