Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER , a Conserved Profibrogenic Long Noncoding RNA

10 Jul 2023

Abstract excerpt

BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis. Fibrosis is associated with heart dysfunction and failure. Myofibroblasts therefore represent attractive therapeutic targets. However, the lack of myofibroblast-specific markers has precluded the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cardiac Fibrosis and Remodeling
Share to Congenital heart defects research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37427428
DOI: 10.1161/circulationaha.122.062601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER , a Conserved Profibrogenic Long Noncoding RNAPMID 37427428Read ↗

Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAsSemantic proximity Read ↗

Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial InfarctionSemantic proximity Read ↗

Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarctionSemantic proximity Read ↗

Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic HeartsSemantic proximity Read ↗

Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosisSemantic proximity Read ↗

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read ↗

Defining Cardiac Recovery at Single Cell ResolutionSemantic proximity Read ↗

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factorsSemantic proximity Read ↗

Targeting RUNX1 in Macrophages Facilitates Cardiac RecoverySemantic proximity Read ↗

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read ↗

Long noncoding RNA Cfast regulates cardiac fibrosisSemantic proximity Read ↗

Dissecting Regulatory Non-Coding GWAS Loci Reveals Fibroblast Causal Genes with Pathophysiological Relevance to Heart FailureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.