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Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair

27 Aug 2024

Abstract excerpt

Cardiac mononuclear phagocytic cells (Cardiac MPCs) participate in maintaining homeostasis and orchestrating cardiac responses upon injury. However, the function of specific MPC subtypes and the related cell fate commitment mechanisms remain elusive in regenerative and nonregenerative hearts due to their cellular heterogeneities. Using spatiotemporal single-cell epigenomic analysis of cardiac MPCs in regenerative...

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PMID: 39190625
DOI: 10.1172/jci175297

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