Article

Direct evidence for upright and helical structure of alpha-synuclein at lipid membranes

2022-06-14

Abstract excerpt

<title>Abstract</title> <p>The aberrant folding of proteins into amyloid aggregates is associated with over 50 diseases. The amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid-membrane surfaces. Despite the importance of lipid surfaces and several decades of structural studies, the 3D-structure of lipid-membrane bound αS is still not known in detail. In particular,...

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Literature Corpus work: 5bf0eb06-60aa-5507-b61d-f6ca5ca0cc4c
DOI: 10.21203/rs.3.rs-1724154/v1

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