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Article

Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles.

Biochimica et biophysica acta - 1 Sept 2016

Pantusa Manuela, Vad Brian, Lillelund Ove, Kjær Lars, Otzen Daniel, Bartucci Rosa

Abstract excerpt

Alpha-synuclein (aSN) is a presynaptic protein with a pathological role in Parkinson's disease (PD). The mutants A30P, E46K and A53T are involved in PD early-onset forms. aSN is natively unfolded but can self-assemble to oligomers and fibrils and binds anionic membranes in a helical conformation. We study the influence of wild-type (wt) aSN and familial variants on the chain order and thermotropic phase behavior...

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Identifiers

PMID: 27177693
DOI: 10.1016/j.bbapap.2016.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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