Article

Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

2022-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid aggregation is associated with many diseases and may also occur in therapeutic protein formulations. Addition of co-solutes is a key strategy to modulate the stability of proteins in pharmaceutical formulations and select inhibitors for drug design in the context of diseases. However, the heterogeneous nature of this multi-component system in terms of structures and mechanisms poses a nu...

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Literature Corpus work: 235e9221-acae-51a9-8e43-9d178446ceae
DOI: 10.1101/2022.10.05.510935

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