Article

Mesoscale proximity labeling to study macro changes to chromatin occupancy

2025-03-15

Abstract excerpt

Proximity labeling traditionally identifies interactomes of a single protein or RNA, though this approach limits mechanistic understanding of biomolecules functioning within complex systems. Here, we demonstrate a strategy for deciphering ligand-induced changes to global biomolecular interactions by enabling proximity labelling at the mesoscale, across an entire cellular system. By inserting nanoscale proximity la...

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Identifiers and source

Literature Corpus work: 5be06313-e7da-5ea8-bc3c-29ea14189e2f
DOI: 10.1101/2025.03.13.643041

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