APEX-seq: RNA subcellular localization by proximity labeling

Abstract excerpt

<title>Abstract</title> <p><bold>We introduce APEX‑seq, a method for RNA sequencing based on direct proximity labeling of RNA using the peroxidase enzyme APEX2. APEX‑seq in nine distinct subcellular locales produced a nanometer-resolution spatial map of the human transcriptome as a resource, revealing extensive and exquisite patterns of localization for diverse RNA classes and transcript isoforms. APEX‑seq should...

Topics

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• Barrier Structure and Function Studies
• Cancer Cells and Metastasis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

0c866e51-bb23-5f4a-b9ae-a3ac874c611b

DOI

10.21203/rs.2.1857/v1