Article

Micromapping (µMap) of HER2 Across Human Breast Cancers: Photocatalytic Proximity Labeling Identifies Primary Resistance Mechanisms and Functional Interactors

2025-06-14

Abstract excerpt

Interactions among receptor tyrosine kinases (RTKs), particularly HER2, are critical in driving the growth of certain breast cancer subtypes. However, the mechanisms of HER2 dependency and resistance to targeted therapies remain unclear. Using photocatalytic micromapping (µMap) proximity labeling, we profiled the HER2 interactome across human breast cancer lines. We identify galectin family proteins as uniquely en...

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Literature Corpus work: 8de5e4c9-353a-5e31-b90b-e27be5d8df9a
DOI: 10.1101/2025.06.10.658685

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