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Article

Tracking chromatin state changes using nanoscale photo-proximity labelling.

Nature - 1 Apr 2023

Seath Ciaran P, Burton Antony J, Sun Xuemeng, Lee Gihoon, Kleiner Ralph E, MacMillan David W C, Muir Tom W

Abstract excerpt

Interactions between biomolecules underlie all cellular processes and ultimately control cell fate. Perturbation of native interactions through mutation, changes in expression levels or external stimuli leads to altered cellular physiology and can result in either disease or therapeutic effects1,2. Mapping these interactions and determining how they respond to stimulus is the genesis of many drug development...

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Identifiers

PMID: 37020029
DOI: 10.1038/s41586-023-05914-y
PMCID: PMC10408239

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