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Article

Proximity labeling identifies a repertoire of site-specific R-loop modulators.

Nature communications - 10 Jan 2022

Yan Qingqing, Wulfridge Phillip, Doherty John, Fernandez-Luna Jose L, Real Pedro J, Tang Hsin-Yao, Sarma Kavitha

Abstract excerpt

R-loops are three-stranded nucleic acid structures that accumulate on chromatin in neurological diseases and cancers and contribute to genome instability. Using a proximity-dependent labeling system, we identified distinct classes of proteins that regulate R-loops in vivo through different mechanisms. We show that ATRX suppresses R-loops by interacting with RNAs and preventing R-loop formation. Our proteomics...

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Identifiers

PMID: 35013239
DOI: 10.1038/s41467-021-27722-6
PMCID: PMC8748879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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