Article

Transcriptomic Stratification of Late-Onset Alzheimer’s Cases Reveals Novel Genetic Modifiers of Disease Pathology

2019-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Late-Onset Alzheimer’s disease (LOAD) is a common, complex genetic disorder well-known for its heterogeneous pathology. The genetic heterogeneity underlying common complex diseases poses a major challenge for targeted therapies and the identification of novel disease-associated variants. Case-control approaches are often limited to examining a specific outcome in a group of heterogenous patients...

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Literature Corpus work: 5bd77397-6fa4-5e70-b77b-0efeeedfc62c
DOI: 10.1101/763516

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