Article

Suppression of neuronal eEF2K alleviates cognitive deficits and apathy-like behavior in APP/PS1 AD model mice

2026-03-08

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by synaptic failure, cognitive impairment and neuropsychiatric symptoms (NPS). Apathy is the most common NPS seen in AD patients, and its underlying mechanisms remain unknown. Here, we investigated the roles of neuronal eukaryotic elongation factor 2 (eEF2) phosphorylation (by its kinase eEF2K) in AD-associat...

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Literature Corpus work: ba8fd8ff-5b0d-503f-9c9d-7933853f346d
DOI: 10.21203/rs.3.rs-8970895/v1

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