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Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

2023-07-06

Abstract excerpt

There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-derived (PD) tumoroids from biobanked tissue samples of advanced high-grade GEP-NEN patients and applied this model for targeted rapid ex vivo pharmacotyping, next-gen...

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Literature Corpus work
5b7f8669-1dc7-512e-84a6-8e0d9fb3a1e5
DOI
10.21203/rs.3.rs-3058974/v1
Open publication

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Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapiesDOI 10.21203/rs.3.rs-3058974/v1
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