Article

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

2022-11-01

Abstract excerpt

<h4>SUMMARY</h4> Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors and poorly-differentiated carcinomas. Treatment options for patients with NENs are limited, in part due to lack of accurate models. To address this need we established the first patient-derived tumor organoids (PDTOs) from pulmonary neuroendocrine tumors and derived PDTOs from an understudied NEN subtype, large cel...

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Literature Corpus work: 3a59fca7-2197-56f3-bff9-413e98ea14cf
DOI: 10.1101/2022.10.31.514549

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