Article

In-depth analysis of the genomic landscape of 86 metastatic neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

2020-08-25

Abstract excerpt

<title>Abstract</title> <p>Metastatic neuroendocrine neoplasms (mNEN) form clinically and genetically heterogeneous malignancies, characterized by distinct prognoses based upon primary tumor localization, functionality, grade, proliferation index and diverse outcomes to treatment. Here, we report the mutational landscape of 86 whole-genome sequenced mNEN. This landscape revealed distinct genomic subpopulations of...

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Literature Corpus work: 4e2d14d8-2b11-526e-bdb7-32f419ba0f06
DOI: 10.21203/rs.3.rs-50333/v1

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