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Article

The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.

Endocrine-related cancer - 1 Mar 2018

Hofving Tobias, Arvidsson Yvonne, Almobarak Bilal, Inge Linda, Pfragner Roswitha, Persson Marta, Stenman Göran, Kristiansson Erik, Johanson Viktor, Nilsson Ola

Abstract excerpt

Experimental models of neuroendocrine tumour disease are scarce, and no comprehensive characterisation of existing gastroenteropancreatic neuroendocrine tumour (GEPNET) cell lines has been reported. In this study, we aimed to define the molecular characteristics and therapeutic sensitivity of these cell lines. We therefore performed immunophenotyping, copy number profiling, whole-exome sequencing and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29444910
DOI: 10.1530/ERC-17-0445
PMCID: PMC5827037

Genes

STS
GOT1
ATRX
HMGA2
MDM2
SMAD4

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