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Article

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets.

Nature communications - 29 Jul 2021

van Riet Job, van de Werken Harmen J G, Cuppen Edwin, Eskens Ferry A L M, Tesselaar Margot, van Veenendaal Linde M, Klümpen Heinz-Josef, Dercksen Marcus W, Valk Gerlof D, Lolkema Martijn P, Sleijfer Stefan, Mostert Bianca

Abstract excerpt

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and genetically heterogeneous malignancies, characterized by distinct prognoses based upon primary tumor localization, functionality, grade, proliferation index and diverse outcomes to treatment. Here, we report the mutational landscape of 85 whole-genome sequenced aNEN. This landscape reveals distinct genomic subpopulations of aNEN...

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Identifiers

PMID: 34326338
DOI: 10.1038/s41467-021-24812-3
PMCID: PMC8322054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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