An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

doi:10.1016/j.cell.2020.10.023

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Article

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

Cell - 25 Nov 2020

Kawasaki Kenta, Toshimitsu Kohta, Matano Mami, Fujita Masashi, Fujii Masayuki, Togasaki Kazuhiro, Ebisudani Toshiki, Shimokawa Mariko, Takano Ai, Takahashi Sirirat, Ohta Yuki, Nanki Kosaku, Igarashi Ryo, Ishimaru Kazuhiro, Ishida Hiroki, Sukawa Yasutaka, Sugimoto Shinya, Saito Yoshimasa, Maejima Kazuhiro, Sasagawa Shota, Lee Hwajin, Kim Hong-Gee, Ha Kyungsik, Hamamoto Junko, Fukunaga Koichi, Maekawa Aya, Tanabe Minoru, Ishihara Soichiro, Hamamoto Yasuo, Yasuda Hiroyuki, Sekine Shigeki, Kudo Atsushi, Kitagawa Yuko, Kanai Takanori, Nakagawa Hidewaki, Sato Toshiro

Abstract excerpt

Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. To fill the scarcity of clinically relevant models of GEP-NEN, we here established 25 lines of NEN organoids and performed their comprehensive molecular characterization. GEP-NEN organoids recapitulated pathohistological...

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PMID: 33159857
DOI: 10.1016/j.cell.2020.10.023

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