Clinically actionable genomic and transcriptomic landscape of advanced neuroendocrine neoplasms.

doi:10.1016/j.medj.2026.101130

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Article

Clinically actionable genomic and transcriptomic landscape of advanced neuroendocrine neoplasms.

Med (New York, N.Y.) - 12 Jun 2026

Kreutzfeldt Simon, Apostolidis Leonidas, Oleś Małgorzata, Krieghoff-Henning Eva, Heilig Christoph E, Heining Christoph, Mock Andreas, Teleanu Maria-Veronica, Hutter Barbara, Gieldon Laura, Klink Barbara, Beck Katja, Richter Daniela, Baude-Müller Annika, Reisinger Eva, Hammer Nils, Kamkar Leila, Pfütze Katrin, Geörg Christina, Lamping Mario, Rieke Damian T, Uhrig Sebastian, Jann Henning, Pape Ulrich-Frank, Allgäuer Michael, Stenzinger Albrecht, Winkler Eva C, Wiedenmann Bertram, Jäger Dirk, Brors Benedikt, Hübschmann Daniel, Schröck Evelin, Keilholz Ulrich, Pavel Marianne, Horak Peter, Glimm Hanno, Fröhling Stefan

Abstract excerpt

BACKGROUND: Epithelial neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of malignancies with limited treatment options. Comprehensive molecular characterization may reveal novel therapeutic opportunities for these clinically challenging tumors. METHODS: Within a nationwide precision oncology program, we performed whole-genome/exome and transcriptome sequencing in 168 patients with a diagnosis of...

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PMID: 42066764
DOI: 10.1016/j.medj.2026.101130

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