Article

Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

2022-12-11

Abstract excerpt

<h4>ABSTRACT</h4> There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-derived (PD) tumoroids from biobanked tissue samples of advanced high-grade GEP-NEN patients and applied this model for targeted rapid ex vivo phar...

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Literature Corpus work: 3dbfb732-e5f1-5d96-95da-5a80f04fa362
DOI: 10.1101/2022.12.10.519855

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