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Article

Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites.

Endocrine-related cancer - 1 Dec 2022

Sun Thomas Yang, Zhao Lan, Van Hummelen Paul, Martin Brock, Hornbacker Kathleen, Lee HoJoon, Xia Li C, Padda Sukhmani K, Ji Hanlee P, Kunz Pamela

Abstract excerpt

High-grade (grade 3) neuroendocrine neoplasms (G3 NENs) have poor survival outcomes. From a clinical standpoint, G3 NENs are usually grouped regardless of primary site and treated similarly. Little is known regarding the underlying genomics of these rare tumors, especially when compared across different primary sites. We performed whole transcriptome (n = 46), whole exome (n = 40), and gene copy number (n = 43)...

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Identifiers

PMID: 36165930
DOI: 10.1530/ERC-22-0015
PMCID: PMC10043760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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