Article

The Impact of Stability Considerations on Genetic Fine-mapping

2023-04-13

Abstract excerpt

Fine-mapping methods, which aim to identify genetic variants responsible for complex traits following genetic association studies, typically assume that sufficient adjustments for confounding within the association study cohort have been made, e.g., through regressing out the top principal components (i.e., residualization). Despite its widespread use, however, residualization may not completely remove all sources...

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Literature Corpus work: 5b791769-0206-5fc6-9955-7443d4cdadcb
DOI: 10.1101/2023.04.11.536456

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